▶ BK21 정보기술사업단-반도체공동연구소 공동세미나 안내 ◀
Current status of fast-scan cyclic voltammetry technique in neuroscience field
- 일 시: 2011년 6월 23일 목요일 10:00
- 장 소: 서울대학교 반도체공동연구소 본관 세미나실 (104동 210호)
- 연 사: 장동표 교수 (Department of Biomedical Engineering, Hanyang University)
Measuring neurochemical changes is crucial for diagnosing and monitoring for several neurological disorders such as Parkinson’s disease, essential tremor, epilepsy, depression and so on. We (Dr. Kendall Lee’s group) have developed a wireless instantaneous neurotransmitter concentration sensor (WINCS) system, which combines digital telemetry with fast-scan cyclic voltammetry (FSCV) for real-time, chemically resolved measurements at an implanted microelectrode. In this talk, I describe the principle and application of WINCS system in in vivo and human patients during deep brain stimulation neurosurgery. WINCS hardware is a micro-processor controlled, MRI-compatible, battery-powered instrument that combines Bluetooth digital telemetry with FSCV and constant potential amperometry. The WINCS base-station software (WINCSware) controls the wireless patient module, filters and processes the received data stream, and displays the results in nearly real time. The WINCS Electrode (WINCStrode) is based on an approved extracellular tungsten electrophysiology electrode that was modified by the addition of a short section of carbon-fiber to enable FSCV recordings. The WINCS hardware, WINCSware, and WINCStrode were used successfully during in vivo experiment and clinical DBS neurosurgery. In addition to the advantages of WINCS system, I discuss the limitations of WINCS system and future works to do for advanced WINCS system.
I have research expertise in the broad area of biomedical engineering and more specifically in the areas of neuroimaging techniques (magnetic resonance imaging and positron emission tomography) and electrochemistry. I received a Ph.D. in Biomedical engineering from Hanyang University in 2002. I then joined as a member of the Neuroscience Research Institute at Gachon Univ. (Under Dr. ZangHee Cho). Until 2009, I continued on neuroimaging researches as an associate professor in the same institute. Then, I moved to the dept. of neurologic surgery, Mayo Clinic, as a visiting scientist and focused on deep brain stimulation and electrochemistry. I have worked closely with Dr. Kendall Lee since I joined his group. Currently, I am working as an associate professor at the department of biomedical engineering, Hanyang University.
담당교수 : 전기공학부 김성준 (문의 : 김진호, Tel. 880-1799 )