<<CMOS RF Biosensor Utilizing Nuclear Magnetic Resonance
- A Circuit Designer\'s Approach to Early Disease Detection>>
1. 일 시 : 2009년 2월 27일 금요일 16:00-17:00
2. 장 소 : 서울대학교 반도체공동연구소 설계연구관 도연홀
3. 연 사 : Donhee Ham (Professor of the Natural Sciences at Harvard)
I will present our recent work that showcases how silicon RF chips can be used not only for wireless RF applications, but also for biosensing aimed at early disease detection. The main function of our RF chip is to manipulate and monitor RF dynamics of protons in water via nuclear magnetic resonance (NMR). Target biological objects such as cancer marker proteins and viruses alter the proton dynamics, which is the basis for our biosensing. The RF chip has a receiver noise figure of only 0.6 dB. This high sensitivity made possible our construction of an entire NMR system around the RF chip in a 100-g platform (our unpublished, newest system; to be published), which is 1200 times lighter, 1100 times smaller, yet 150 times more mass sensitive than a state-of-the-art commercial benchtop NMR system. With an ability of sensing one target biomolecule in 40 trillion water molecules, our system is a circuit designer’s approach to pursue early disease detection in a low-cost, hand-help platform. [If time permits, I will also present our recent reflection pulse oscillator work and/or delay-based temperature sensor work].
Donhee Ham is the Loeb Associate Professor of the Natural Sciences at Harvard. He received the B.S. degree in physics from Seoul National U., where he graduated summa cum laude with the Valedictorian Prize, Presidential Prize, and Physics Gold Medal. He received the Ph.D. degree in EE from Caltech, winning the Wilts Prize, best thesis award in EE, for his examination of the statistical physics in electrical circuits. His awards include the recognition by MIT Tech Review as among the world\'s top 35 young innovators (TR35). His work experiences include IEEE ISSCC &ASSCC tech program committees, IEEE JSSC guest editor, and various advisory positions on ultrafast electronics, science at the nanoscale, and bio-silicon interface. He is a co-editor of CMOS Biotechnology with Springer. His current research is on (1) RF, analog &mixed-signal ICs, (2) GHz-THz plasmonic transport in quantum wires, (3) soliton electronics, and (4) applications of CMOS ICs in biotechnology.
담당교수 : 전기컴퓨터공학부 정덕균 (문의 : 김은영, Tel. 880-1306 )