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세미나

[세미나] [전기전자세미나] 4/13 (목) Biointerface Technologies: Neural Probes for Brain Mapping and Cellular Biochips

2017-04-06l 조회수 1147




연사: 윤의식  University of Michigan 교수

¾일시: 2017년 4월 13일(목) 오후 5:00~6:00

¾장소: 서울대학교 제1공학관(301동) 118호

Abstract:

       In this talk, I will review two research topics that my group has been working on: neural interface technologies and cellular interface microchips. The first topic covers the evolution of Michigan neural probe technologies toward scaling up the number of recording sites, enhancing the recording reliability, and introducing multi-modalities in neural interface. We investigated scaling of probe geometry to reduce probe surface area in the form of lattice probes, while exploring polymer materials for providing flexibility in the shank body to reduce micromotion effects. As a part of multi-modality, we monolithically integrated optical waveguides on the Michigan probe to bring optical stimulation capability in addition to electrical recording for optogenetics study.  The second topic covers the microfluidic platforms that my group has developed for robust single cell capture, long-term clonal culture of heterogeneous single cells for drug screening and differentiation study, and selective cell retrieval for further phenotypic and genotypic analysis. A growing body of evidence supports the presence of cancer “stem-like” cells (CSC) in many cancers. In the CSC model only a limited subset of the heterogeneous population actually retains the ability initiate new tumors, grow, and metastasize. Understanding and analyzing this heterogeneity at single cell level is important to improve our basic understanding of cancer biology.  The developed platform grants orders of magnitude higher throughput in analyzing single cells than conventional methods. Single-cell retrieval technique will be introduced to selectively release the target single cells with high precision, allowing for characterizing single cell genotype after observing, in assays, the phenotypic responses of the cells

Biography:

l 학력

1990   Ph.D. degree in electrical engineering from the University of Michigan, Ann Arbor

1984   MS, electronics engineering, Seoul National University

1982   BS, electronics engineering, Seoul National University

l 주요 경력

2008 ~ 현재   Professor, Dept. of Electrical and Biomedical engineering, University of Michigan

2005 ~ 2008   Professor, Dept. of Electrical engineering, University of Minnesota, Minneapolis

1996 ~ 2005   Professor, Dept. of Electrical engineering, KAIST

1994 ~ 1996   Member of the Technical Staff at Silicon Graphics Inc. in Mountain View, CA

1990 ~ 1994   Fairchild Research Center of the National Semiconductor Corp. in Santa Clara, CA

l 상훈

1999    co-recipient of the Student Paper Award at the IEEE International Microwave Symposium

2000    co-recipient of the Student Paper Award at the IEEE International Microwave Symposium

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